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Inhibition of Replication of Herpes Simplex Virus in Mouse Macrophages by Interferons

Institute of Virus Research, German Cancer Research Center, Heidelberg, F.R.G.
and¹ Department of Virology, The Hebrew University, Hadassah Medical School, Jerusalem, Israel

The replication of herpes simplex virus (HSV) type 1 in macrophages grown from spleen cells of mouse strains susceptible to HSV infection in vivo was very sensitive to interferon (IFN). Different types of mouse IFN (, , ) exhibited similar antiviral activities. However, treatment of cells with IFN- in combination with IFN- or IFN- resulted in a synergistic inhibition of virus growth. As shown by assaying HSV DNA polymerase, IFN inhibited expression of the -genes. Inhibition of enzyme induction correlated well with the reduction of viral yield. Induction of HSV DNA polymerase was delayed by IFN in a dose-dependent manner. These results show that IFN inhibits HSV replication at an early step prior to or during the synthesis of -proteins.

Keywords: HSV-1, interferon, mouse macrophages, HSV DNA polymerase

Received 6 March 1985; accepted 15 July 1985.