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The role of Haemagglutinin-Neuraminidase Glycoprotein Cell Surface Expression in the Survival of Sendai Virus-infected BHK-21 Cells

¹ Department of Microbiology, University of Geneva, C.M.U., 9 avenue de Champel, 1211 Geneva 4, Switzerland
and² Division of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, U.S.A.

A temperature-sensitive mutant of Sendai virus with a lesion in the haemagglutinin-neuraminidase protein (HN) (ts 271) was used to study the effect of HN cell surface expression on the fate of infected BHK-21 cells. The total amount of HN was reduced in ts 271 virus-infected cells at the non-permissive temperature (38 °C) presumably due to degradation of the protein. At this temperature, neither HN nor a modified form of HN were found expressed at the surface of the infected cells. BHK-21 cells infected with ts 271 were nevertheless killed by the infection at 38 °C as well as at 30 °C. These results ruled out the hypothesis that the lack of HN cell surface expression could be the unique requirement allowing BHK cell survival.

Keywords: Sendai virus, HN glycoprotein, cytopathic effect

Received 17 June 1985; accepted 2 August 1985.

This article has been cited by other articles:

				T. Takimoto, T. Bousse, E. C. Coronel, R. A. Scroggs, and A. Portner Cytoplasmic Domain of Sendai Virus HN Protein Contains a Specific Sequence Required for Its Incorporation into Virions J. Virol., December 1, 1998; 72(12): 9747 - 9754. [Abstract] [Full Text] [PDF]