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Acid-labile Interferon Produced in Human Peripheral Leukocytes by Induction with Sendai Virus

Department of Microbiology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-Ku, Kyoto 602, Japan

An acid-labile interferon- (IFN-) exists in IFN produced in human peripheral leukocytes with Sendai virus. This activity was found in fractions of molecular weights about 100 000 (100K), 58K and 44K. The IFN activity in the 100K fraction was neutralized with anti-HuIFN- serum alone, but activity in the 58K and 44K fractions was neutralized only by a mixture of anti-HuIFN- and anti-HuIFN- sera.

Keywords: HuIFN-, acid-labile IFN, human peripheral leukocytes, Sendai virus

Received 15 April 1985; accepted 7 August 1985.