HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bruce, M. E. Search for Related Content PubMed PubMed Citation Articles by Bruce, M. E. Agricola Articles by Bruce, M. E.

Agent Replication Dynamics in a Long Incubation Period Model of Mouse Scrapie

AFRC & MRC Neuropathogenesis Unit, West Mains Road, Edinburgh EH9 3JF, U.K.

The dynamics of scrapie agent replication in brain and spleen following intracerebral or intraperitoneal infection were investigated in a model with particularly long incubation periods [IM mice (Sinc^p7) infected with 87V scrapie]. In contrast to other mouse scrapie models previously investigated, there was no delay in onset of replication (‘zero phase’) in spleen using either route of infection, For both routes infectivity levels reached a plateau in spleen, which was maintained for at least 250 days in intraperitoneally infected mice. An infectivity plateau was also apparent in brain following intracerebral infection, suggesting that there may be constraints on agent replication in brain during the later part of the incubation period. In addition, the efficiency of the intraperitoneal route to produce disease was found to be particularly low for this model.

Keywords: scrapie, replication dynamics, incubation period

Received 20 May 1985; accepted 4 September 1985.

This article has been cited by other articles:

				J. C. Bartz, C. DeJoia, T. Tucker, A. E. Kincaid, and R. A. Bessen Extraneural Prion Neuroinvasion without Lymphoreticular System Infection J. Virol., September 15, 2005; 79(18): 11858 - 11863. [Abstract] [Full Text] [PDF]

				J. C. Bartz, J. M. Aiken, and R. A. Bessen Delay in onset of prion disease for the HY strain of transmissible mink encephalopathy as a result of prior peripheral inoculation with the replication-deficient DY strain J. Gen. Virol., January 1, 2004; 85(1): 265 - 273. [Abstract] [Full Text] [PDF]

				A. Aguzzi, F. L Heppner, M. Heikenwalder, M. Prinz, K. Mertz, H. Seeger, and M. Glatzel Immune system and peripheral nerves in propagation of prions to CNS Br. Med. Bull., June 1, 2003; 66(1): 141 - 159. [Abstract] [Full Text] [PDF]

				G. A. H. Wells, S. A. C. Hawkins, A. R. Austin, S. J. Ryder, S. H. Done, R. B. Green, I. Dexter, M. Dawson, and R. H. Kimberlin Studies of the transmissibility of the agent of bovine spongiform encephalopathy to pigs J. Gen. Virol., April 1, 2003; 84(4): 1021 - 1031. [Abstract] [Full Text] [PDF]

				J. C. Bartz, A. E. Kincaid, and R. A. Bessen Rapid Prion Neuroinvasion following Tongue Infection J. Virol., December 6, 2002; 77(1): 583 - 591. [Abstract] [Full Text] [PDF]

				F. Montrasio, R. Frigg, M. Glatzel, M. A. Klein, F. Mackay, A. Aguzzi, and C. Weissmann Impaired Prion Replication in Spleens of Mice Lacking Functional Follicular Dendritic Cells Science, May 19, 2000; 288(5469): 1257 - 1259. [Abstract] [Full Text]