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Release of Progeny Virus from Cells Infected with Simian Rotavirus SA11

Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Apartado Postal 70228, Cd. Universitaria D.F., 04510 México

Analysis of cells infected with simian rotavirus SA11 at late times of infection indicated that the particles were associated with membranes and the cytoskeleton. Although a large amount of cellular and non-structural viral proteins were released at these times, probably by cellular lysis, only virus with an outer layer was found outside the cells, while virus without an outer layer remained associated with the cells, probably with membranes and the cytoskeleton. Inhibition of glycosylation by tunicamycin did not abolish cell lysis but inhibited the liberation of particles and the non-glycosylated precursors of the structural and non-structural viral glycoproteins. These results indicate that immature virus was tightly associated with the structural matrix of the cell.

Keywords: rotavirus, simian, morphogenesis, release, tunicamycin

Received 29 April 1985; accepted 29 August 1985.

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