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J Gen Virol 66 (1985), 503-508; DOI 10.1099/0022-1317-66-3-503
© 1985 Society for General Microbiology
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Effect of Borna Disease Virus Infection on Athymic Rats

S. Herzog1, K. Wonigeit3, K. Frese2, H. J. Hedrich4 and R. Rott1

and1 Institut für Virologie
and2 Veterinär-Pathologie, Justus-Liebig-Universität Giessen, D-6300 Giessen
3 Klinik für Abdominal- und Transplantationschirurgie
and4 Zentralinstitut für Versuchstierzucht, D-3000 Hannover, Federal Republic of Germany

Homozygous athymic nude rats (rnu/rnu) infected intracerebrally with Borna disease virus produced relatively high titres of infectious virus in the central nervous system. However, no clinical signs of disease or pathological alterations could be found during a 100 day observation period. In contrast, heterozygous euthymic albino littermates (rnu/+), which were used as controls, reacted in a similar manner to immunocompetent Lewis rats. They developed behavioural alterations which coincided with encephalitis and retinitis. The results obtained confirm our previous concept that the genesis of Borna disease, at least in rats, is attributed to a cellular immune response.

Keywords: Borna disease, immunopathology, pathogenesis

Received 28 August 1984; accepted 31 October 1984.


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