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The Cytotoxic Response to Murine Cytomegalovirus. II. In vitro Requirements for Generation of Cytotoxic T Cells

Department of Microbiology, The John Curtin School of Medical Research, Australian National University, Canberra, A.C.T. 2601, Australia

A cytotoxic response to murine cytomegalovirus (MCMV) was obtained by the culture of lymph node cells from mice inoculated with MCMV into both hind footpads 7 days previously. The cytotoxicity was mediated by Thy1.2⁺, Lyt2⁺, H-2-restricted effector cells and was virus-specific. Investigation of the in vitro conditions established that T cell proliferation was necessary for optimal generation of cytotoxicity, that proliferation was dependent upon Thy1.2⁺, Lyt2⁺ cell populations and that supernatants from concanavalin A-activated spleen cells enhanced the levels of cytotoxicity obtained.

Keywords: MCMV, cytotoxic T cells, in vitro

Received 4 September 1984; accepted 19 November 1984.

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