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Catabolic Sites of Human Interferon-

Institute of General Physiology, University of Siena, 53100 Siena, Italy

Recombinant human interferon- (HuIFN-) injected into rabbits disappeared from the circulation more rapidly than natural IFN-. The latter displayed an initial decay curve more rapid than that for natural HuIFN- although 4 h after injection plasma levels were similar. This result suggests that IFN- has pharmacokinetic properties different to those of IFN- which may be explained by considerable and simultaneous hepatic and renal catabolism. Surprisingly, the hepatic uptake of recombinant (unglycosylated) IFN- was more marked than uptake of natural IFN-. Moreover, both IFN- preparations were cleared by the isolated and perfused kidney and once again the recombinant IFN disappeared more rapidly. This result does not conform with the suggestion that IFN- exists as a tetramer which would not be filtered by the glomerulus, but is consistent with the pharmacokinetic behaviour shown in vivo.

Keywords: IFN, pharmacokinetic properties, liver, kidney

Received 7 August 1984; accepted 20 November 1984.

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