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Mechanisms of Neutralization of Influenza Virus by IgM

Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, U.K.

IgM which neutralized influenza virus infectivity by over 99% prevented the attachment of only half the virus population to BHK cells at 37 °C. However, the half of the population that attached to cells was not internalized. Loss of infectivity brought about by IgM is thus totally different from that caused by neutralizing IgG which does not inhibit attachment or penetration.

Keywords: influenza virus, IgM, neutralization

Received 8 October 1984; accepted 14 December 1984.

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