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The Induction of Myeloid Leukaemias by Rauscher Murine Leukaemia Virus

Department of Pathology, Medical Faculty, Dr Molewaterplein 50, 3000 Dr Rotterdam
and¹ Department of Microbiology
and² Department of Genetics, Free University, de Boelelaan 1087, 1081 HV Amsterdam, The Netherlands

A number of cloned viral preparations isolated from Rauscher virus-producing JLS-V5 cells were compared in their competence to induce different types of leukaemias. All preparations were able to induce myeloid leukaemias, but the induction of lymphatic or erythroid leukaemias was also observed. Serial infection of newborn mice with either cell-free extracts or serum from animals suffering from a myeloid leukaemia did not result in the occurrence of relatively more myeloid leukaemias nor did the infection with virus harvested from ascites fluid of permanent myeloid cell lines. It appears that the mechanism by which myeloid leukaemias are induced is not virus-specific.

Keywords: myeloid leukaemias, Rauscher murine leukaemia virus

Received 27 July 1984; accepted 19 December 1984.