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Injection of Anti-thy-1.2 Serum Breaks Genetic Resistance of Mice against Herpes Simplex Virus

¹ Institut fur Virusforschung, Deutches Krebsforschungszentrum, Im Neuenheimer Feld 280, 6900 Heidelberg, F.R.G.
² Department of Internal and Occupational Diseases, Medical School, 51-367 Wroclaw, Poland
and³ Institute of Immunology and Oncology, Bayer AG, Wuppertal, F.R.G.

Nude mice have been shown to be as resistant to intraperitoneal infection with herpes simplex virus type 1 (HSV) as their heterozygous littermates. Here we document that both activation of natural killer (NK) cells and interferon induction were normal in nu/nu mice after injection of HSV. Injection of silica caused increased mortality by HSV in C57BL/6 mice. Silica, in addition, led to a significant reduction of NK cell activity but had no effect on the interferon response. Treatment of C57BL/6 mice with anti-asialo GM1 (an antiserum with a predominant effect on NK cells) caused complete abolition of the NK cell response, but had no effect on interferon induction or virus-induced mortality. In further studies a monoclonal anti-thy-1.2 antibody was utilized which possessed high activity in vivo in depleting T cell responses in mice. Injection of anti-thy-1.2 decreased NK cell activation but was without effect on the interferon response. Unexpectedly, in view of the data in nu/nu mice, this antibody increased HSV-induced mortality in C57BL/6 mice. Similar data were obtained when anti-thy-1.2 was injected into nu/nu mice. Our results are compatible with the hypothesis that T cell precursors sensitive to anti-thy-1.2 present in homozygous nude mice play a role in resistance against HSV. Furthermore, the data in the euthymic mice may indicate a role of T cells in the primary resistance of mice against HSV.

Keywords: HSV-1, NK cells, T cells, anti-thy-1.2

Received 19 November 1984; accepted 28 January 1985.

This article has been cited by other articles:

				W. P. Halford, J. W. Balliet, and B. M. Gebhardt Re-Evaluating Natural Resistance to Herpes Simplex Virus Type 1 J. Virol., September 15, 2004; 78(18): 10086 - 10095. [Abstract] [Full Text] [PDF]