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Differences in the Processing of Secreted Glycoprotein A Induced by Marek's Disease Virus and Herpesvirus of Turkeys

Department of Pathology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565
and¹ Department of Molecular Biology, Tokai University School of Medicine, Bohseidai, Isehara 259-11, Japan

The steps from the precursor to the processed forms of a secreted glycoprotein (gA) of Marek's disease virus (MDV) and of herpesvirus of turkeys (HVT) were examined by two-dimensional gel electrophoresis of immunoprecipitates from the cell lysate and medium of infected cultures with monoclonal antibodies. Differences between MDV-and HVT-gA were particularly observed in isoelectric points of the glycosylated or unglycosylated precursor forms.

Keywords: MDV, HVT, monoclonal antibodies, glycoproteins

Received 18 September 1984; accepted 9 January 1985.