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1 Unité INSERM 196, Institut Curie, 26 Rue d'Ulm, 75231 Paris Cedex 05, France
and2 Institute of Immunology and Virology, University of Zurich, Switzerland
Binding of 125I-labelled human recombinant DNA interferons (IFNs) alpha-2, beta and gamma was compared on various human lymphoid cells and embryonic fibroblasts. While binding constants were within an order of magnitude for all three interferons (10-10 to 10-9 M), no competition was observed between IFN-
on the one hand and IFN-
2 and IFN-
on the other. However, consistent with previous reports, IFN-2 and IFN- competed for presumably common receptors. Depending on the cell type, binding sites for IFN- were expressed in different numbers compared to those for IFN-2 and IFN-. These direct comparative binding studies support the hypothesis that the receptor system for IFN- is unrelated to the IFN-/ system.
Keywords: interferon, receptors, human cells
Received 23 November 1984;
accepted 22 January 1985.
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