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Department of Veterinary Microbiology and Pathology
and1 U.S. Department of Agriculture, Animal Disease Research Unit, Washington State University, Pullman, Washington 99164, U.S.A.
Antigenic relatedness between the virion-associated proteins of caprine arthritis-encephalitis, visna and progressive pneumonia viruses was examined. Antigenic cross-reactivity was assessed by immunoprecipitation of disrupted, radiolabelled virus with goat, sheep and rabbit antisera, followed by resolution of the immunoprecipitation products by SDS-polyacrylamide gel electrophoresis. The results indicate that antigenic cross-reactivity between the caprine and ovine virus isolates involves all of the major virion-associated proteins and glycoproteins. The common antigenic determinants exhibited by virion structural proteins are immunogenic in goats, sheep and rabbits.
Keywords: lentiviruses, cross-reactivity, immunoprecipitation
Received 21 November 1984;
accepted 1 February 1985.
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