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Cell Cycle Position and Expression of Encephalomyocarditis Virus in Mouse Embryo Fibroblasts

Department of Microbiology, Guy's Hospital Medical School, London Bridge, London SE1 9RT, U.K.

Infection of mouse embryo fibroblasts in G₁ or S phase with encephalomyocarditis virus gave different kinetics of viral RNA synthesis. In S phase cells, RNA synthesis was faster and reached higher levels than in G₁ cells. Virus-specified proteins were fewer in G₁ cells than in S cells during the early stage of the infection and c.p.e. in G₁ cells appeared about 4 h later than in S cells. Addition of a cellular factor with ability to affect cell conformation had an inhibitory effect on viral RNA synthesis.

Keywords: EMC virus, cell cycle, RNA and protein synthesis

Received 20 February 1985; accepted 4 April 1985.

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