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J Gen Virol 66 (1985), 1795-1799; DOI 10.1099/0022-1317-66-8-1795
© 1985 Society for General Microbiology
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Affinity-purified Varicella-Zoster Virus Glycoprotein gp1/gp3 Stimulates the Production of Neutralizing Antibody

Zofia Wroblewska1, Donald Gilden1,3, Marguerite Green1, Mary Devlin3 and Abbas Vafai2

1 Multiple Sclerosis Research Center, The Wistar Institute of Anatomy and Biology, 36th Street at Spruce, Philadelphia, Pennsylvania 19104
2 Department of Microbiology
and3 Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, U.S.A.

Varicella-zoster virus glycoprotein gp1/gp3 was purified by affinity chromatography using anti-gp1/gp3 monoclonal antibody 19.1 linked to CNBr-activated Sepharose CL-4B. Rabbits immunized with purified glycoprotein gp1/gp3 developed monospecific neutralizing antibody.

Keywords: VZV, glycoproteins, neutralizing antibody

Received 22 January 1985; accepted 8 May 1985.




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Copyright © 1985 by the Society for General Microbiology.