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Production of Cell-mediated Immune Response to Herpes Simplex Virus by Immunization with Anti-idiotypic Heteroantisera

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, U.K.

Three BALB/c monoclonal antibodies capable of neutralizing herpes simplex virus type 1 (HSV-1) were used to prepare rabbit anti-idiotypic antisera. Affinity-purified antibodies from four of these rabbits were used to immunize mice by repeated subcutaneous injection over a period of 6 to 7 weeks: the mice were then challenged with HSV-1 subcutaneously in the ear pinna. Measurement of ear swelling showed that prior administration of anti-idiotypic serum could generate dose-dependent delayed-type hypersensitivity responses.

Keywords: HSV-1, anti-idiotypic antibodies, delayed hypersensitivity

Received 29 January 1985; accepted 29 April 1985.

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