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Viral DNA Sequences Detected in a Hamster Liposarcoma Induced by Bovine Papillomavirus Type 4

¹ Department of Zoology, University of Edinburgh, Edinburgh EH9 3JT
and² Department of Veterinary Pathology, University of Glasgow Veterinary School, Bearsden, Glasgow G61 1QH, U.K.

Following intradermal inoculation of bovine papillomavirus type 4 (BPV-4) into a Syrian hamster, a liposarcoma developed at the inoculation site 20 months later. The DNA of this tumour contained multiple copies of the BPV-4 genome which existed in a free unintegrated state. Unintegrated viral DNA and viral DNA isolated from virus particles from bovine alimentary tract papillomas revealed identical cleavage patterns with CpG methylation-resistant and -sensitive restriction enzymes: apparently there was no gross methylation of CpG sites in either case. The entire BPV-4 genome appeared to be represented in the tumour DNA.

Keywords: papillomavirus, carcinogen, hamster liposarcoma

Received 22 March 1985; accepted 24 September 1985.

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