| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Biology, University of Essex, Wivenhoe Park, Colchester CO4 3SQ
2 National Institute for Biological Standards and Control, Holly Hill, London NW3 6RB
and3 Department of Microbiology, University of Reading, London Road, Reading RG1 5AQ, U.K.
We have cloned and sequenced the complete genome of a strain of poliovirus type 3 (23127) isolated during an outbreak of poliomyelitis in Finland. The genome is 7435 nucleotides long excluding the 3' poly(A) stretch and is 95.5% homologous at the amino acid level to the previously sequenced type 3 strain, P3/Leon/37. The most striking feature of the presented sequence is the extent of amino acid substitutions relative to P3/Leon/37 and other type 3 strains in areas of known antigenic importance. The major antigenic determinant for virus neutralization (site 1), located at residues 89 to 100 of VP1, has three amino acid substitutions and there are six substitutions in site 3, a composite site made up of sequences from VP1 and VP3. The variation in these regions probably accounts for the observed unusual antigenicity and may explain why the virus was able to spread in a well-vaccinated community. Sequence comparisons imply that the virus is not derived from the currently used live attenuated vaccine.
Keywords: poliovirus, nucleotide sequence, Finland, poliomyelitis
Received 18 April 1986;
accepted 12 June 1986.
This article has been cited by other articles:
|
|
 |
|
  C. C. Burns, J. Shaw, R. Campagnoli, J. Jorba, A. Vincent, J. Quay, and O. Kew Modulation of Poliovirus Replicative Fitness in HeLa Cells by Deoptimization of Synonymous Codon Usage in the Capsid Region. J. Virol., April 1, 2006; 80(7): 3259 - 3272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. DeJesus, D. Franco, A. Paul, E. Wimmer, and J. Cello Mutation of a Single Conserved Nucleotide between the Cloverleaf and Internal Ribosome Entry Site Attenuates Poliovirus Neurovirulence J. Virol., November 15, 2005; 79(22): 14235 - 14243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Binford, F. Maldonado, M. A. Brothers, P. T. Weady, L. S. Zalman, J. W. Meador III, D. A. Matthews, and A. K. Patick Conservation of Amino Acids in Human Rhinovirus 3C Protease Correlates with Broad-Spectrum Antiviral Activity of Rupintrivir, a Novel Human Rhinovirus 3C Protease Inhibitor Antimicrob. Agents Chemother., February 1, 2005; 49(2): 619 - 626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Martín, G. Dunn, R. Hull, V. Patel, and P. D. Minor Evolution of the Sabin Strain of Type 3 Poliovirus in an Immunodeficient Patient during the Entire 637-Day Period of Virus Excretion J. Virol., April 1, 2000; 74(7): 3001 - 3010. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. Muir, U. Kammerer, K. Korn, M. N. Mulders, T. Poyry, B. Weissbrich, R. Kandolf, G. M. Cleator, and A. M. van Loon Molecular Typing of Enteroviruses: Current Status and Future Requirements Clin. Microbiol. Rev., January 1, 1998; 11(1): 202 - 227. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
