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Independent Regulation of the Antiviral States Induced by MuIFN-/ and by MuIFN-

Department of Microbiology, The University of Texas Medical Branch, Galveston, Texas 77550, U.S.A.

The stability profiles of the antiviral states induced in L-929 cells against mengovirus by murine interferons MuIFN-/ and by MuIFN- were shown to be different. Treatment of cells with combinations of IFN-/ and IFN- have previously been shown to result in a potentiated expression of the antiviral state. Here we report studies of the stabilities of the antiviral states induced by various combinations of IFN-/ and IFN- and that the regulation of the antiviral states induced by IFN-/ and IFN- were independent of each other.

Keywords: interferon (MuIFN-/ and -), antiviral state, mengovirus

Received 1 April 1986; accepted 12 June 1986.

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