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1 Department of Microbiology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514
and2 Department of Measles Virus, National Institute of Health, 4-7-1 Gakuen, Musashi-Murayama, Tokyo 190-12, Japan
Six monoclonal antibodies (MAbs) against the haemagglutinin-neuraminidase (HN) protein and three against the fusion (F) protein of mumps virus were obtained. Anti-HN MAbs were classified into three antigen-specific groups in competitive binding assays. All of the anti-HN MAbs showed virus-neutralizing and haemolysis-inhibiting activities and inhibited fusion from without (FFWO). Three of them inhibited fusion from within (FFWI) and the cell-to-cell spread of infection. The most effective MAb in inhibiting FFWI possessed neuraminidase-inhibiting activity and little haemagglutination-inhibiting activity. All anti-F MAbs inhibited virus-induced haemolysis but none of them inhibited FFWO, FFWI or the cell-to-cell spread of infection.
Keywords: mumps virus, HN protein, monoclonal antibodies, fusion inhibition
Received 26 February 1986;
accepted 1 July 1986.
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