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DNA Sequence of the Major Capsid Protein Gene of Herpes Simplex Virus Type 1

A. J. Davison

MRC Virology Unit, Institute of Virology, University of Glasgow, Church Street, Glasgow G11 5JR, U.K.

The DNA sequence of the region of the herpes simplex virus type 1 genome encoding the major capsid protein was determined. The predicted protein contains 1374 amino acid residues and has a molecular weight of 149075. Comparisons of the amino acid sequence of this protein with those predicted from the published DNA sequences of two other herpesviruses, varicella-zoster virus and Epstein-Barr virus, resulted in the identification of the major capsid protein gene in each genome.

Keywords: HSV-1, VZV, EBV, capsid protein

Present address: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National institutes of Health, Bethesda, Maryland 20892, U.S.A.

Received 10 June 1986; accepted 16 July 1986.

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