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J Gen Virol 67 (1986), 2335-2340; DOI 10.1099/0022-1317-67-11-2335
© 1986 Society for General Microbiology
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Establishment of a Mouse Model for Human Rhinovirus Infection

Fay H. Yin and Nancy B. Lomax

E. I. du Pont de Nemours & Company, Central Research & Development Department, Experimental Station, Wilmington, Delaware 19898, U.S.A.

We describe here a mouse model for rhinovirus infection using a variant of human rhinovirus type 2 (HRV2/H) which replicated 50- to 300-fold in the lungs of BALB/c mice. The variant virus differed only marginally from HRV2/H according to various biochemical parameters. Use of a photosensitive inoculum and pretreatment of the animals with actinomycin D were necessary for detection of reproducible and significant levels of virus replication. This mouse model of rhinovirus infection is the first example of human rhinovirus replication in a non-primate mammal, and provides an important link for the development of rhinovirus therapy or prophylaxis.

Keywords: human rhinovirus, host range, mouse model

Received 20 March 1986; accepted 9 July 1986.


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