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Veterinary Medical Research Institute and Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, U.S.A.
At times after conjunctival inoculation with bovine herpesvirus type 1 (BHV-1), representing the acute and latent phases of infection, rabbit trigeminal ganglia were examined for the presence of BHV-1 nucleic acids by in situ hybridization using a 3H-labelled BHV-1 DNA probe. During the acute phase of virus infection, both BHV-1 DNA and RNA were detected in ganglionic neurons and occasionally in adjacent satellite cells. However, during the latent phase of infection only viral RNA was detectable in involved neurons. Viral RNA appeared restricted to the nucleus of latently infected cells and was present in varying amounts in individual cells. These results indicate that the BHV-1 genome is transcriptionally active in ganglionic neurons during latent infection.
Keywords: BHV-1, latent infection, in situ hybridization, transcription
Present address: Department of Veterinary Science, North Dakota State University, P.O. Box 5406, Fargo, North Dakota 58105, U.S.A.
Present address: Veterinary Diagnostic Center, University of Nebraska-Lincoln, Lincoln, Nebraska 68583-0907, U.S.A.
Present address: Molecular Genetics Inc., 10320 Bren Road East, Minnetonka, Minnesota 55343, U.S.A.
Received 7 May 1986;
accepted 16 July 1986.
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