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1 Deutsches Primatenzentrum, Kellnerweg 4, D-3400 Göttingen, F.R.G.
2 Tierärztliche Hochschule, Institut für Virologie, Bünteweg 17, D-3000 Hannover, FRG
and3 NCI Frederick Cancer Research Facility, Frederick, Maryland 21701, U.S.A.
Two glycopolypeptides with molecular weights 160000 and 120000 (gp120) are regularly recognized by human immunodeficiency virus (HIV)-specific antisera in lysates of cells persistently infected with HIV. In the present study, gp120 was characterized as the major envelope glycopolypeptide of HIV. Gp120 was identified as the external viral glycoprotein by radiosequencing and by its presence in purified virus. However gp120 was predominantly shed as a soluble protein into the culture fluid. Furthermore gp120 was precipitated by sera from horses infected with equine infectious anaemia virus (EIAV), but not by sera from uninfected animals. This may indicate conserved epitopes common to the envelopes of HIV and EIAV.
Keywords: HIV, envelope glycoprotein, immunoprecipitation
Received 26 July 1986;
accepted 29 July 1986.
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