| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Deutsches Primatenzentrum, Kellnerweg 4, D-3400 Göttingen, F.R.G.
2 Tierärztliche Hochschule, Institut für Virologie, Bünteweg 17, D-3000 Hannover, FRG
and3 NCI Frederick Cancer Research Facility, Frederick, Maryland 21701, U.S.A.
Two glycopolypeptides with molecular weights 160000 and 120000 (gp120) are regularly recognized by human immunodeficiency virus (HIV)-specific antisera in lysates of cells persistently infected with HIV. In the present study, gp120 was characterized as the major envelope glycopolypeptide of HIV. Gp120 was identified as the external viral glycoprotein by radiosequencing and by its presence in purified virus. However gp120 was predominantly shed as a soluble protein into the culture fluid. Furthermore gp120 was precipitated by sera from horses infected with equine infectious anaemia virus (EIAV), but not by sera from uninfected animals. This may indicate conserved epitopes common to the envelopes of HIV and EIAV.
Keywords: HIV, envelope glycoprotein, immunoprecipitation
Received 26 July 1986;
accepted 29 July 1986.
This article has been cited by other articles:
|
|
 |
|
  X. Yang, I. Lipchina, S. Cocklin, I. Chaiken, and J. Sodroski Antibody Binding Is a Dominant Determinant of the Efficiency of Human Immunodeficiency Virus Type 1 Neutralization J. Virol., November 15, 2006; 80(22): 11404 - 11408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Yang, S. Kurteva, X. Ren, S. Lee, and J. Sodroski Stoichiometry of Envelope Glycoprotein Trimers in the Entry of Human Immunodeficiency Virus Type 1 J. Virol., October 1, 2005; 79(19): 12132 - 12147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Jinno-Oue, N. Shimizu, Y. Soda, A. Tanaka, T. Ohtsuki, D. Kurosaki, Y. Suzuki, and H. Hoshino The Synthetic Peptide Derived from the NH2-terminal Extracellular Region of an Orphan G Protein-coupled Receptor, GPR1, Preferentially Inhibits Infection of X4 HIV-1 J. Biol. Chem., September 2, 2005; 280(35): 30924 - 30934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Yang, S. Kurteva, S. Lee, and J. Sodroski Stoichiometry of Antibody Neutralization of Human Immunodeficiency Virus Type 1 J. Virol., March 15, 2005; 79(6): 3500 - 3508. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Zhu, E. Chertova, J. Bess Jr., J. D. Lifson, L. O. Arthur, J. Liu, K. A. Taylor, and K. H. Roux Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions PNAS, December 23, 2003; 100(26): 15812 - 15817. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nisole, E. A. Said, C. Mische, M.-C. Prevost, B. Krust, P. Bouvet, A. Bianco, J.-P. Briand, and A. G. Hovanessian The Anti-HIV Pentameric Pseudopeptide HB-19 Binds the C-terminal End of Nucleolin and Prevents Anchorage of Virus Particles in the Plasma Membrane of Target Cells J. Biol. Chem., May 31, 2002; 277(23): 20877 - 20886. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Chertova, J. W. Bess Jr., B. J. Crise, R. C. Sowder II, T. M. Schaden, J. M. Hilburn, J. A. Hoxie, R. E. Benveniste, J. D. Lifson, L. E. Henderson, et al. Envelope Glycoprotein Incorporation, Not Shedding of Surface Envelope Glycoprotein (gp120/SU), Is the Primary Determinant of SU Content of Purified Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus J. Virol., May 3, 2002; 76(11): 5315 - 5325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Binley, R. W. Sanders, A. Master, C. S. Cayanan, C. L. Wiley, L. Schiffner, B. Travis, S. Kuhmann, D. R. Burton, S.-L. Hu, et al. Enhancing the Proteolytic Maturation of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins J. Virol., February 22, 2002; 76(6): 2606 - 2616. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Clayton, D. P. Kotler, S. K. Kuwada, T. Morgan, C. Stepan, J. Kuang, J. Le, and J. Fantini Gp120-Induced Bob/GPR15 Activation : A Possible Cause of Human Immunodeficiency Virus Enteropathy Am. J. Pathol., November 1, 2001; 159(5): 1933 - 1939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Haddrick, C. R. Brown, R. Plishka, A. Buckler-White, V. M. Hirsch, and H. Ginsberg Biologic Studies of Chimeras of Highly and Moderately Virulent Molecular Clones of Simian Immunodeficiency Virus SIVsmPBj Suggest a Critical Role for Envelope in Acute AIDS Virus Pathogenesis J. Virol., July 15, 2001; 75(14): 6645 - 6659. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. K. Ullrich, J. E. Groopman, and R. K. Ganju HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases Blood, August 15, 2000; 96(4): 1438 - 1442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Sanders, L. Schiffner, A. Master, F. Kajumo, Y. Guo, T. Dragic, J. P. Moore, and J. M. Binley Variable-Loop-Deleted Variants of the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Can Be Stabilized by an Intermolecular Disulfide Bond between the gp120 and gp41 Subunits J. Virol., June 1, 2000; 74(11): 5091 - 5100. [Abstract] [Full Text]
|
|
|
|
|
|
E. R. Johnston and K. Radke The SU and TM Envelope Protein Subunits of Bovine Leukemia Virus Are Linked by Disulfide Bonds, both in Cells and in Virions J. Virol., March 15, 2000; 74(6): 2930 - 2935. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. Shutt and D. Soll HIV-induced T-cell syncytia release a two component T-helper cell chemoattractant composed of Nef and Tat J. Cell Sci., January 11, 1999; 112(22): 3931 - 3941. [Abstract] [PDF]
|
|
|
|
|
|
D. Shutt, L. Jenkins, E. Carolan, J Stapleton, K. Daniels, R. Kennedy, and D. Soll T cell syncytia induced by HIV release. T cell chemoattractants: demonstration with a newly developed single cell chemotaxis chamber J. Cell Sci., January 1, 1998; 111(1): 99 - 109. [Abstract] [PDF]
|
|
|
|
 |
|
 C. Callebaut, E. Jacotot, B. Krust, and A. G. Hovanessian Response Science, May 20, 1994; 264(5162): 1162 - 1165. [PDF]
|
|
|
|
|
|
J. Moore, J. McKeating, R. Weiss, and Q. Sattentau Dissociation of gp120 from HIV-1 virions induced by soluble CD4 Science, November 23, 1990; 250(4984): 1139 - 1142. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
