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J Gen Virol 67 (1986), 2543-2548; DOI 10.1099/0022-1317-67-11-2543
© 1986 Society for General Microbiology
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Complete Sequence of the Major Nucleocapsid Protein Gene of Human Parainfluenza Type 3 Virus: Comparison with Other Negative Strand Viruses

Robert C. Jambou, Narayanasamy Elango, Sundararajan Venkatesan and Peter L. Collins

Laboratory of Infectious Diseases, Building 7, Room 100, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, U.S.A.

The sequence of the major nucleocapsid protein (NP) mRNA and its encoded protein were deduced by sequencing a cDNA clone representing the complete mRNA. The cDNA sequence was confirmed by dideoxynucleotide sequencing of purified viral genomic RNA by primer extension using synthetic oligonucleotides. The NP mRNA contains 1641 nucleotides exclusive of poly(A) and encodes an NP protein of 515 amino acids. Alignment of the human parainfluenza type 3 virus (PF3) NP protein sequence with that of Sendai virus showed that the two proteins shared considerable sequence identity (58.8%). Additional comparisons provided highly significant statistical evidence that the PF3 NP protein sequence is related to those of measles and canine distemper viruses, but there was no evidence of relatedness with the nucleocapsid proteins of respiratory syncytial virus, influenza B virus, or vesicular stomatitis virus.

Keywords: parainfluenza type 3 virus, nucleocapsid protein, sequence homology

Received 11 April 1986; accepted 31 July 1986.


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