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J Gen Virol 67 (1986), 2799-2802; DOI 10.1099/0022-1317-67-12-2799
© 1986 Society for General Microbiology
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T Cell-Macrophage Interactions in the Immune Response to Herpes Simplex Virus: the Significance of Interferon-{gamma}

J. M. Seid1, M. Liberto2, L. Bonina2, K.-N. Leung1 and A. A. Nash1

1 Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, U.K.
and2 Department of Microbiology, University of Messina, Italy

The antiviral properties of a herpex simplex virus type 1-specific ‘helper’ T cell clone were investigated. The clone was found to be deficient in interleukin 2 production, although it produced interleukin 3 and interferon-{gamma} upon stimulation with the virus in vitro. Supernatants containing these lymphokines were observed to increase the virocidal activity of macrophages in vitro and furthermore induced these cells to mediate cytotoxic activity against virus-infected target cells. Macrophage activation was linked to the presence of interferon-{gamma} in the clone supernatant. The implications of these results for protection against this virus in vivo are discussed.

Keywords: HSV-1, interferon (MuIFN-{gamma}), T cells

Received 20 May 1986; accepted 21 August 1986.


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J. Melchjorsen, F. S. Pedersen, S. C. Mogensen, and S. R. Paludan
Herpes Simplex Virus Selectively Induces Expression of the CC Chemokine RANTES/CCL5 in Macrophages through a Mechanism Dependent on PKR and ICP0
J. Virol., February 22, 2002; 76(6): 2780 - 2788.
[Abstract] [Full Text] [PDF]


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