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Host-adaptive Antigenic Variation in Bunyaviruses

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, U.K.

Bunyamwera virus and snowshoe hare virus (family Bunyaviridae) were passaged up to six times through mosquito cells in culture and the resultant viruses were compared to the input, mammalian cell-passed virus using monoclonal antibodies raised against the input virus. The mosquito cell-adapted virus population consisted of mutants which were better adapted to replication in the new host than was the input mammalian cell-passed virus and were differentially susceptible to neutralization by antibody.

Keywords: host-adaptive antigenicity, neutralization, Bunyamwera virus, snowshoe hare virus

Received 5 March 1986; accepted 18 August 1986.