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Time and Temperature Dependence of Influenza Virus Membrane Fusion at Neutral pH

Bradley P. Boyer

Departments of Pediatrics, Medicine and Microbiology, University of Rochester, Rochester, New York 14642, U.S.A.

The time course and temperature requirements for fusion of influenza virus membranes with liposomes at pH 7.5 were found to be consistent with the requirements for cell entry. At 37 °C, fusion was most rapid during the first 5 min and then continued more slowly up to at least 1 h. The amount of fusion increased semilogarithmically with increasing temperature up to 50 °C.

Keywords: influenza virus, membrane, fusion

Present address: Eastman Kodak Research Laboratories, Rochester, New York 14650, U.S.A.

Received 7 July 1986; accepted 15 August 1986.

This article has been cited by other articles:

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