HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Tanishita, O. Articles by Yamanishi, K. Search for Related Content PubMed PubMed Citation Articles by Tanishita, O. Articles by Yamanishi, K. Agricola Articles by Tanishita, O. Articles by Yamanishi, K.

Persistent Infection of Rats with Haemorrhagic Fever with Renal Syndrome Virus and their Antibody Responses

¹ Kanonji Institute, Research Foundation for Microbial Diseases, Osaka University, Kanonji, Kagawa 768,
² Department of Preventive Medicine,
³ Department of Virology
and⁴ Quarters for Experimentally Infected Animals, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565,
and⁵ Department of Pathology, National Institute of Health, Kamioosaki, Sinagawa-ku, Tokyo 141, Japan

Newborn (within 24 h after birth), 1-week-old and 6-week-old (adult) rats were inoculated with a Hantaan-related virus (B-1) and attempts were made to isolate the virus from various organs. Virus-specific antigens were detected in various organs of newborn rats. Moreover virus could be isolated from almost all their organs even 25 weeks after infection. In contrast, in rats infected at 6 weeks of age the virus could be isolated from various organs but its concentration decreased progressively with time. The levels of haemagglutination-inhibiting (HI) and neutralizing antibodies to B-1 virus in the sera were measured. In adult rats, HI antibodies were first detected 2 weeks after infection and their titre rose to a maximum after 5 weeks. On the other hand, in newborn rats the levels of antibodies remained low until 5 or 6 weeks after infection and started to increase to a high level more than 9 weeks after infection. Furthermore, in rats infected soon after birth IgM antibodies predominated for a long time and these antibodies also neutralized infectivity at a high level. These data suggest that the induction of a high titre of neutralizing antibodies mainly of the IgM type does not result in virus clearance in new born rats and that cellular immunity may be important for virus clearance in vivo.

Keywords: Hantaan virus, persistent infection, antibody response

Received 7 April 1986; accepted 28 August 1986.

This article has been cited by other articles:

				M. Kramski, H. Meisel, B. Klempa, D. H. Kruger, G. Pauli, and A. Nitsche Detection and Typing of Human Pathogenic Hantaviruses by Real-Time Reverse Transcription-PCR and Pyrosequencing Clin. Chem., November 1, 2007; 53(11): 1899 - 1905. [Abstract] [Full Text] [PDF]

				B. J. Meyer and C. Schmaljohn Accumulation of Terminally Deleted RNAs May Play a Role in Seoul Virus Persistence J. Virol., February 1, 2000; 74(3): 1321 - 1331. [Abstract] [Full Text]

				D. Netski, B. H. Thran, and S. C. St. Jeor Sin Nombre Virus Pathogenesis in Peromyscus maniculatus J. Virol., January 1, 1999; 73(1): 585 - 591. [Abstract] [Full Text] [PDF]