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J Gen Virol 67 (1986), 583-589; DOI 10.1099/0022-1317-67-3-583
© 1986 Society for General Microbiology
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Human Papillomavirus Type 16 DNA in Genital Tumours: A Pathological and Molecular Analysis

Dario di Luca1, Silvana Pilotti2, Bernardina Stefanon3, Antonella Rotola1, Paolo Monini1, Mauro Tognon1, Giuseppe de Palo3, Franco Rilke2 and Enzo Cassai1

1 Institute of Microbiology, University of Ferrara, Via L. Borsari 46, 44100 Ferrara
and2 Division of Pathology and Cytology
and3 Division of Clinical Oncology ‘A’, Instituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, 20100 Milano, Italy

The presence of human papillomavirus type 16 (HPV16) DNA in 34 genital tract tumours of Italian female patients was investigated by Southern blot hybridization in high stringency conditions. HPV16 DNA was detected in 16 neoplasias, including cervical invasive and intraepithelial lesions as well as vulvar intraepithelial neoplasias and, to a lesser extent, vulvar invasive carcinomas. Appropriate control tissues included in the study were negative. The data suggest that integration of viral DNA had occurred in most tumours, both in invasive and in intraepithelial lesions. HPV16 variants or defective genomes, lacking the BamHI restriction site, were detected in three tumours.

Keywords: HPV16, genital tract, neoplasia

Received 10 June 1985; accepted 2 December 1985.


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[Abstract] [Full Text] [PDF]


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