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1 National Institute for Biological Standards and Control, Holly Hill, Hampstead, London NW3 6RB, U.K.
and2 Research Institute of Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, California 92037, U.S.A.
A 4 month old child was immunized with a vaccine containing the Sabin live attenuated vaccine strains of all three serotypes of poliovirus. The antigenic and molecular evolution of the Sabin strain of poliovirus type 3 was then followed throughout the entire period of virus excretion. Novel strains appeared at 8, 42 and 52 days post-vaccination and were the products of both intertypic recombination between type 2 and type 3 poliovirus in regions of the genome coding for non-structural proteins and of point mutations in the region coding for the structural proteins. Excretion of virus continued for 73 days. All strains examined reacted with all monoclonal antibodies specific for the main immunodominant antigenic site of type 3 poliovirus, but variation was observed at other, immunorecessive sites. These findings have possible implications for the evolution of the virus in vaccinees or in epidemics and are consistent with the known antigenic stability of the virus.
Keywords: poliovirus, vaccine, evolution
Received 12 November 1985;
accepted 17 December 1985.
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