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Lack of Detectable Reverse Transcriptase Activity in Human and Chimpanzee Sera with a High Infectivity for Non-A, Non-B Hepatitis

¹ Hepatitis Division
and² Department of Biochemistry, The Tokyo Metropolitan Institute of Medical Science, Bunkyo-Ku, Tokyo 113
³ Institute of Immunology, Bunkyo-Ku, Tokyo 113
and⁴ Immunology Division, Jichi Medical School, Minamikawachi-Machi, Tochigi-Ken 329-04, Japan

A serum sample from a patient with hepatitis and samples from two experimentally infected chimpanzees, all with a high infectivity for non-A, non-B hepatitis, were tested for reverse transcriptase. Biopsy confirmed that the hepatocytes of the chimpanzees that received these sera contained the characteristic tubular structures associated with non-A, non-B hepatitis. None of these three sera revealed detectable enzyme activity. We have not been able to confirm the association of reverse transcriptase activity with non-A, non-B hepatitis reported recently.

Keywords: non-A, non-B hepatitis, hepatitis, post-transfusion, reverse transcriptase

Received 26 November 1985; accepted 6 January 1986.