HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Pastoret, P.-P. Articles by Thomas, R. Search for Related Content PubMed PubMed Citation Articles by Pastoret, P.-P. Articles by Thomas, R. Agricola Articles by Pastoret, P.-P. Articles by Thomas, R.

Logical Description of Bovine Herpesvirus Type 1 Latent Infection

Virology Department, Faculty of Veterinary Medicine, University of Liège, Rue des Vétérinaires, 45, B-1070 Brussels
and¹ Department of Molecular Biology, Faculty of Sciences, Free University of Brussels, Rue des Chevaux, 67, B-1640 Rhode-St-Genèse, Belgium

Description of the interactions between bovine herpesvirus type 1 (BHV-1) and cattle was performed by the method known as kinetic logic. This logical formalization uses variables with two possible values, 1 and 0, which tell whether an element is present or not at a significant level. To each variable is associated a function which tells if the element is being produced at a significant rate. The temporal relation between a variable and its associated function is given by specific time delays. The BHV-1 infection system is described by a set of five logical equations which tell in what conditions each function is on or off. The five functions are: V, development of viral multiplication; R, development of reactivation of the latent virus; A, development of an immune response; G, establishment of the viral genome; M, development of a memory of a first immune response. Several examples are detailed in a dynamic analysis, in connection with known experimental data.

Keywords: bovine herpesvirus type 1, logical analysis, latent infection

Received 1 July 1985; accepted 24 January 1986.

This article has been cited by other articles:

				F. Schynts, F. Meurens, B. Detry, A. Vanderplasschen, and E. Thiry Rise and Survival of Bovine Herpesvirus 1 Recombinants after Primary Infection and Reactivation from Latency J. Virol., December 1, 2003; 77(23): 12535 - 12542. [Abstract] [Full Text] [PDF]

				M. Lemaire, V. Weynants, J. Godfroid, F. Schynts, G. Meyer, J.-J. Letesson, and E. Thiry Effects of Bovine Herpesvirus Type 1 Infection in Calves with Maternal Antibodies on Immune Response and Virus Latency J. Clin. Microbiol., May 1, 2000; 38(5): 1885 - 1894. [Abstract] [Full Text]