HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Nguyen, T. D. Articles by Aynaud, J. M. Search for Related Content PubMed PubMed Citation Articles by Nguyen, T. D. Articles by Aynaud, J. M. Agricola Articles by Nguyen, T. D. Articles by Aynaud, J. M.

Neutralizing Secretory IgA and IgG Do Not Inhibit Attachment of Transmissible Gastroenteritis Virus

Tien Dung Nguyen

INRA, Laboratoire de Pathologie Porcine, 37380 Nouzilly, France

Secretory IgA (sIgA) and IgG from porcine milk and serum, respectively, [³H]uridine-labelled virus, swine testis and pig kidney cell lines were used to examine the neutralized virus-cell interaction. Transmissible gastroenteritis virus (TGEV), 99.99% neutralized by immunoglobulin, was able to attach to the cells. Moreover, sIgA enhanced virus attachment. However, the neutralized virus was unable to enter cells, as demonstrated by the action of proteinase K which removed it from the cell surface. It was also found that pre-attached virus was still neutralizable and that IgG and sIgA had similar TGEV-neutralizing capacities.

Keywords: TGEV, neutralization, attachment

Permanent address: National Institute of Veterinary Research, Bachmai, Hanoi, Vietnam.

Received 20 August 1985; accepted 23 January 1986.

This article has been cited by other articles:

				H. Marcotte and M. C. Lavoie Oral Microbial Ecology and the Role of Salivary Immunoglobulin A Microbiol. Mol. Biol. Rev., March 1, 1998; 62(1): 71 - 109. [Abstract] [Full Text] [PDF]