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Enhancement by Carprofen or Indomethacin of Interferon Induction by 10-Carboxymethyl-9-Acridanone in Murine Cell Cultures

Institute for Virus Research, German Cancer Research Center, Postfach 101949, D-6900 Heidelberg, F.R.G.
¹ Institute of Microbiology, University of Turin, Via Santena 9, I 10126 Turin, Italy
and² Department of Medical Immunology, University of Marburg, D-3550 Marburg, F.R.G.

Non-steroidal anti-inflammatory drugs such as carprofen or indomethacin enhanced interferon (IFN) production induced by suboptimal concentrations of 10-carboxy-methyl-9-acridanone (CMA) in murine cell cultures. This effect was observed in fibroblasts and in different populations of leukocytes as in peritoneal exudate and spleen cells, and was most pronounced in bone marrow-derived macrophages. Carprofen was the most effective compound causing an up to 500-fold increase of CMA-induced IFN production in pure bone marrow-derived macrophages. In these macrophage cultures the potentiating effect on CMA-induced IFN production by carprofen and indomethacin did not depend on inhibition of cyclooxygenase.

Keywords: interferon induction, 10-carboxymethyl-9-acridanone, indomethacin, carprofen

Received 29 October 1985; accepted 26 February 1986.