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J Gen Virol 67 (1986), 1315-1325; DOI 10.1099/0022-1317-67-7-1315
© 1986 Society for General Microbiology
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A Filamentous Distribution for the Herpes Simplex Virus Type 2-encoded Major DNA-binding Protein

D. S. C. Rose1,{dagger}, K. Shriver3, D. S. Latchman2 and N. B. LaThangue1,{ddagger}

1 Imperial Cancer Research Fund Tumour Immunology Unit
and2 Department of Zoology, University College London, Gower Street, London WC1E 6BT, U.K.
and3 Genetic Systems Corporation, 3005 First Avenue, Seattle, Washington 98121, U.S.A.

Monoclonal antibodies reacting with the herpes simplex virus (HSV)-encoded major DNA-binding protein defined an intracellular filamentous network. This network was associated predominantly with the infected cell nucleus and occurred in cells infected with HSV type 2. It did not co-distribute with microfilaments, microtubules or intermediate filaments, and DNA synthesis was required for its formation. We suggest explanations for the occurrence and function of this novel filamentous network structure.

Keywords: HSV-2, DNA-binding protein, cytoskeleton

{dagger} Present address: The Royal Free Hospital, Pond Street, London NW3 2QG, U.K.

{ddagger} Present address: Cancer Research Campaign Eukaryotic Molecular Genetics Research Group, Department of Biochemistry, Imperial College of Science and Technology, South Kensington, London SW7 2A7, U.K.

Received 11 December 1985; accepted 26 March 1986.


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S. L. Uprichard and D. M. Knipe
Conformational Changes in the Herpes Simplex Virus ICP8 DNA-Binding Protein Coincident with Assembly in Viral Replication Structures
J. Virol., July 1, 2003; 77(13): 7467 - 7476.
[Abstract] [Full Text] [PDF]


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