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J Gen Virol 67 (1986), 1475-1478; DOI 10.1099/0022-1317-67-7-1475
© 1986 Society for General Microbiology
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Fc Receptor(s) Induced by Human Cytomegalovirus Bind Differentially with Human Immunoglobulin G Subclasses

T. Murayama1, S. Natsuume-Sakai2, K. Shimokawa1 and T. Furukawa1

1 Department of Microbiology, Kanazawa Medical University, Uchinada, Ishikawa 920-02
and2 Department of Immunobiology, Institute for Cancer Research, Kanazawa University, Kanazawa 920, Japan

The IgG subclass specificity of Fc receptor(s) induced on cells by infection with human cytomegalovirus (HCMV) was studied in a binding assay by using infected cells and purified iodinated IgG of various subclasses from HCMV seronegative healthy adult donors. All four human IgG subclasses bound to HCMV-infected cells, with the following relative magnitudes: IgG1 >= IgG4 > IgG2 > IgG3. The IgG subclass specificity of the Fc receptor was further analysed in an inhibition assay by using fragments prepared from purified human IgG by papain digestion, and using unlabelled subclass proteins. Fc but not Fab fragments inhibited the binding of 125I-labelled human IgG to HCMV-infected cells. The biological role of the Fc receptor in HCMV infection is discussed.

Keywords: HCMV, Fc receptor(s), IgG subclasses

Received 16 December 1985; accepted 14 April 1986.


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