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J Gen Virol 67 (1986), 1727-1732; DOI 10.1099/0022-1317-67-8-1727
© 1986 Society for General Microbiology
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Subclinical Infections in Mice Resulting from the Modulation of a Lethal Dose of Semliki Forest Virus with Defective Interfering Viruses: Neurochemical Abnormalities in the Central Nervous System

A. D. T. Barrett1,{dagger}, A. J. Cross2,{ddagger}, T. J. Crow2, J. A. Johnson2, A. R. Guest1 and N. J. Dimmock1

1 Department of Biological Sciences, University of Warwick, Coventry CV4 7AL
and2 Division of Psychiatry, MRC Clinical Research Centre, Harrow HA1 3UJ, U.K.

The lethal encephalitis caused in mice by Semliki Forest virus (SFV) is modulated to a subclinical infection by administration of defective interfering SFV, although virus still multiplies both in the central nervous system (CNS) and systemically. Here we report that such infections result in unique and selective changes in the normal levels of CNS neurotransmitters some of which persist after infectious virus can no longer be detected. This represents a previously undocumented category of infection which may have a bearing on the aetiology of those human neurological and neuropsychiatric diseases to which viruses are believed to contribute.

Keywords: SFV, DI virus, neurochemical abnormalities

{dagger} Present address: Department of Microbiology, University of Surry, Guildford GU2 5XH, U.K.

{ddagger} Present address: Department of Psychology, University of Manchester, Manchester, U.K.

Received 16 April 1986; accepted 22 April 1986.




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Copyright © 1986 by the Society for General Microbiology.