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An Antiviral State Induced in HeLa Cells by Microinjected Poly(rI)·Poly(rC)

¹ Laboratoire de Biochimie des Protéines, UA CNRS 541, Université de Montpellier II, Place Eugène Bataillon, 34060 Montpellier Cedex, France
and² Département de Biologie Moléculaire, Université Libre de Bruxelles, 67 rue des Chevaux, 1640 Rhode Saint Genèse, Belgium

The direct introduction with micropipettes of poly(rI)·poly(rC) into the cytoplasm of several human cell lines inhibited the multiplication of vesicular stomatitis virus. This antiviral activity was at least partly due to interferon (IFN) production and secretion from the injected cells since it was species-specific, partly neutralized by IFN antibodies and was transmissible to non-adjacent cells. This suggests a mechanism of IFN induction involving the internalization of poly(rI)·poly(rC) and its interaction with an intracellular target.

Keywords: interferon induction, poly(rI)·poly(rC), microinjection

Received 22 January 1986; accepted 12 May 1986.

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