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Suppression of Friend Virus-induced Leukaemia in Mice by Tuftsin

Mirosaw uczak²

¹ Division of Protein Chemistry, Tufts University School of Medicine, Boston, Massachusetts 02111, U.S.A.
^2* Department of Virology, Institute of Biostructure, Medical Academy of Warsaw, Chaubiskiego 5, 02004 Warsaw, Poland
and³ Cancer Research Center and Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111, U.S.A.

A significant decrease in mortality was observed when 25 µg of the tetrapeptide tuftsin was given to DBA/2J mice 5 days before infection with Friend leukaemia virus (FLV). The same effect was observed when tuftsin was given 5 days before and twice a week for 3 weeks after FLV infection. No effect was observed when the same amount of tuftsin was given 1 day before infection. A 5 µg dose of tuftsin given 5 days before and twice-weekly for 3 weeks had no effect on leukaemia induced by FLV infection. These findings showed that time and dosage were critical to the protective effect of tuftsin against virus-induced leukaemia.

Keywords: tuftsin, anticancer, Friend leukaemia virus

Received 3 December 1985; accepted 27 May 1986.