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Reduced Temperature Can Block Different Glycoproteins at Different Steps during Transport to the Plasma Membrane

Microbiology Department, University of Geneva Medical School, C.M.U., 9 avenue de Champel, 1211 Geneva 4, Switzerland

Reduced temperature has been shown to block the cell surface expression of Sendai virus haemagglutinin-neuraminidase (HN) and fusion (F₀) glycoproteins at different steps of their intracellular transport. At 20 °C, HN was confined to the rough endoplasmic reticulum or cis Golgi compartment, while F₀ acquired complete resistance to digestion by endo--N-acetylglucosaminidase-H and therefore was blocked at a more distal location in the pathway of cell surface expression. The significance of these results for different pathways of transport to the cell surface is discussed.

Keywords: Sendai virus, glycoproteins, transport pathways, temperature effect

Received 18 April 1986; accepted 6 June 1986.