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J Gen Virol 68 (1987), 2647-2654; DOI 10.1099/0022-1317-68-10-2647
© 1987 Society for General Microbiology
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Relationship between Inhibition of Cell Growth and of Transferrin Receptor Expression by Interferon (IFN) {alpha}: Studies in IFN-sensitive and IFN-resistant Daudi Cells

Françoise Besancon1, Flora Silbermann1, Michel Dron2, Michael G. Tovey2, Ming Nguy Thang1 and Marie-Françoise Bourgeade1

1 U.245 INSERM, Centre INSERM, Hôpital St-Antoine, 184 rue du Faubourg St-Antoine, 75012 Paris
and2 Laboratoire d'Oncologie Virale, Institut de Recherches Scientifiques sur le Cancer, 94802 Villejuif Cédex, France

We previously showed that treatment of different cell lines with interferon-{alpha}(IFN-{alpha}) concurrently inhibited both cell growth and the rise observed in 125I-labelled transferrin binding when cells are exposed to culture conditions that stimulate proliferation. To gain insight into the relationship between these two IFN-induced inhibitory processes, we investigated the effect of IFN-{alpha} on the binding of 125I-labelled transferrin to Daudi cells sensitive or resistant to its antiproliferative action. We found a close correlation between the ability of IFN-{alpha} to inhibit cell growth and to inhibit transferrin receptor expression. Since growth inhibition induced by other agents is not always accompanied by an inhibition of transferrin receptor expression, the previous and present observations suggest that the inhibitory effect of IFN on this expression is at least one of the mechanisms by which IFN inhibits cell proliferation. We also observed that IFN-{alpha} did not modify transferrin receptor biosynthesis in IFN-sensitive Daudi cells, suggesting that IFN-{alpha} may change the processing of the transferrin receptor molecules, making them unable to bind transferrin.

Keywords: IFN-{alpha}, antiproliferative action, transferrin receptor expression

Received 8 June 1987; accepted 25 June 1987.




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Copyright © 1987 by the Society for General Microbiology.