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J Gen Virol 68 (1987), 2789-2796; DOI 10.1099/0022-1317-68-11-2789
© 1987 Society for General Microbiology
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Molecular Cloning and Sequencing of the F and 22K Membrane Protein Genes of the RSS-2 Strain of Respiratory Syncytial Virus

H. N. Baybutt and C. R. Pringle

Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, U.K.

The nucleotide sequences of the adjacent genes coding for the F protein and 22K protein of the RSS-2 strain of human respiratory syncytial (RS) virus were determined from cDNA clones of genomic RNA. Comparison of these sequences and the inferred amino acid sequences of the F and 22K proteins with the corresponding published sequences of another subgroup A virus, the A2 strain of RS virus, reveals extensive overall homology (>95%) at both the nucleotide and amino acid levels, even though these two viruses were isolated 15 years apart in different continents. The intergenic region and the hydrophobic amino-terminal signal sequence of the F proteins of the two viruses, however, are much less conserved.

Keywords: RS virus, cDNA sequences, membrane proteins

Received 10 June 1987; accepted 13 July 1987.


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