HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Löwer, J. Articles by Kurth, R. Search for Related Content PubMed PubMed Citation Articles by Löwer, J. Articles by Kurth, R. Agricola Articles by Löwer, J. Articles by Kurth, R.

Genome Analysis and Reverse Transcriptase Activity of Human Teratocarcinoma-derived Retroviruses

Paul Ehrlich Institut, Paul Ehrlich Strasse 42-44, D-6000 Frankfurt 70, F.R.G.

Five of five human teratocarcinomas cultured in vitro could be induced to synthesize retrovirus-like particles, albeit in extremely low amounts. The accumulation and purification of the human teratocarcinoma-derived retrovirus (HTDV) from one of these cell lines allowed characterization of its genomic material as high mol. wt. (60S) RNA. Partial purification of HTDV-associated RNA-dependent DNA polymerase (reverse transcriptase) has also been achieved. HTDVs are easily distinguishable from the exogenous human T-lymphotropic viruses and human immunodeficiency viruses by morphological, biological and immunological criteria.

Keywords: retroviruses, teratocarcinoma, genome analysis

Received 11 February 1987; accepted 28 July 1987.

This article has been cited by other articles:

				W. Seifarth, C. Baust, A. Murr, H. Skladny, F. Krieg-Schneider, J. Blusch, T. Werner, R. Hehlmann, and C. Leib-Mosch Proviral Structure, Chromosomal Location, and Expression of HERV-K-T47D, a Novel Human Endogenous Retrovirus Derived from T47D Particles J. Virol., October 1, 1998; 72(10): 8384 - 8391. [Abstract] [Full Text] [PDF]

				M. T. Boyd, B. Foley, and I. Brodsky Evidence for Copurification of HERV-K-Related Transcripts and a Reverse Transcriptase Activity in Human Platelets From Patients With Essential Thrombocythemia Blood, November 15, 1997; 90(10): 4022 - 4030. [Abstract] [Full Text] [PDF]