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J Gen Virol 68 (1987), 2933-2938; DOI 10.1099/0022-1317-68-11-2933
© 1987 Society for General Microbiology
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Identification of Human Papillomavirus Type 16 E7 Protein by Monoclonal Antibodies

Tilman Oltersdorf1, Klaus Seedorf2,{dagger}, Walter Röwekamp2 and Lutz Gissmann1

1 Institut für Virusforschung
and2 Institut für Zell- und Tumorbiologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-6900 Heidelberg, F.R.G.

A number of human papillomavirus (HPV) type 16 proteins have recently been identified in human cervical carcinoma cell lines using polyclonal antisera against papillomavirus gene products expressed in escherichia coli. E7 protein has been found to be the most abundant papillomavirus protein in these cells. Here we describe a panel of monoclonal antibodies recognizing a 15K Mr non-glycosylated cytoplasmic HPV-16 E7 protein. One of the antibodies cross-reacted with HPV-18 E7 protein.

Keywords: HPV-16, E7 protein, monoclonal antibodies

{dagger} Present address: Genentech Inc., Department of Developmental Biology, 460 Point San Bruno Boulevard, South San Francisco, California 94080, U.S.A.

Received 2 April 1987; accepted 22 July 1987.


This article has been cited by other articles:


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 Proc. Natl. Acad. Sci. USAHome page
K. Smith-McCune, D. Kalman, C. Robbins, S. Shivakumar, L. Yuschenkoff, and J. M. Bishop
Intranuclear localization of human papillomavirus 16 E7 during transformation and preferential binding of E7 to the Rb family member p130
PNAS, June 8, 1999; 96(12): 6999 - 7004.
[Abstract] [Full Text] [PDF]


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