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J Gen Virol 68 (1987), 263-272; DOI 10.1099/0022-1317-68-2-263
© 1987 Society for General Microbiology
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Abortive Infection by Bacteriophage Me1 of Escherichia coli K12 Strains Bearing the Plasmid ColV, I-K94

Claudia F. L. Reakes, Alexander A. F. Gann{dagger}, Freda T. Rossouw{ddagger} and Robin J. Rowbury

Department of Botany and Microbiology, University College London, Gower Street, London WC1E 6BT, U.K.

Bacteriophage Me1 is unable to grow on Escherichia coli strains harbouring the ColV, I-K94 plasmid. The nature of this inhibition was investigated, and it was found not to be due to restriction, superinfection exclusion or receptor-mediated resistance, but to be a new example of plasmid-mediated abortive infection. Investigation of events occurring during abortive Me1 infection revealed some differences from previously described cases, especially with regard to late protein synthesis, which did occur, albeit showing abnormal amounts of some proteins. No major differences were observed in membrane permeability of productively and abortively infected cells. Phage-directed DNA synthesis was reduced in abortively infected cells. Comparative studies of Me1 and T4 revealed a striking similarity despite some minor differences.

Keywords: phage Me1, ColV plasmid, abortive infection

{dagger} Present address: Department of Molecular Biology, University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh EH9 3JR, U.K.

{ddagger} Present address: Department of Genetics, University of the Witwatersrand, Johannesburg, South Africa.

Received 24 June 1986; accepted 6 October 1986.




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Copyright © 1987 by the Society for General Microbiology.