| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Microbiology, National Defense Medical College, Tokorozawa, Saitama 359
and1 Department of Immunology, Medical Institute for Bioregulation Research, Kyushu University, Fukuoka 812, Japan
The contribution of phagocytes to the early protection of mice inoculated intravenously with influenza virus was investigated in phagocyte-depleted mice. Following the inoculation of a sublethal dose of influenza virus, virus titres in the liver and lung of both untreated and carrageenan-treated mice were reduced rapidly by day 1 and decreased slowly to reach an undetectable level by day 7. The titres in 
-irradiated mice decreased transiently by day 1 and increased progressively thereafter to kill all of the hosts by day 8. The clearance of virus from blood at the early stage of infection was retarded by -irradiation but not by carrageenan treatment. In addition, increase in virus titres in the liver and lung in the early stage of the infection was prevented by adoptive transfer with syngeneic polymorphonuclear leukocytes into -irradiated mice. No significant rise of neutralizing antibody was detectable by day 3 after the inoculation, in any of the three groups of mice. These observations imply that -sensitive and carrageenan-resistant polymorphonuclear leukocytes play a protective role at the early stage in the infection, whereas fixed macrophages or natural killer cells, both of which are carrageenan-sensitive and -resistant, scarcely participate in the early phase.
Keywords: influenza A virus, PMN, viraemia, early protection
Received 21 May 1986;
accepted 24 October 1986.
This article has been cited by other articles:
|
|
 |
|
  J. Chen Comment on "Chronic Alcohol Consumption Increases the Severity of Murine Influenza Virus Infections" J. Immunol., November 1, 2008; 181(9): 5813 - 5813. [Full Text] [PDF]
|
|
|
|
 |
|
 H. Fujisawa Neutrophils Play an Essential Role in Cooperation with Antibody in both Protection against and Recovery from Pulmonary Infection with Influenza Virus in Mice J. Virol., March 15, 2008; 82(6): 2772 - 2783. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Wareing, A. Lyon, C. Inglis, F. Giannoni, I. Charo, and S. R. Sarawar Chemokine regulation of the inflammatory response to a low-dose influenza infection in CCR2-/- mice J. Leukoc. Biol., March 1, 2007; 81(3): 793 - 801. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Castro, A. Guerrero-Plata, G. Suarez-Real, P. A. Adegboyega, G. N. Colasurdo, A. M. Khan, R. P. Garofalo, and A. Casola Antioxidant Treatment Ameliorates Respiratory Syncytial Virus-induced Disease and Lung Inflammation Am. J. Respir. Crit. Care Med., December 15, 2006; 174(12): 1361 - 1369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Tumpey, A. Garcia-Sastre, J. K. Taubenberger, P. Palese, D. E. Swayne, M. J. Pantin-Jackwood, S. Schultz-Cherry, A. Solorzano, N. Van Rooijen, J. M. Katz, et al. Pathogenicity of Influenza Viruses with Genes from the 1918 Pandemic Virus: Functional Roles of Alveolar Macrophages and Neutrophils in Limiting Virus Replication and Mortality in Mice J. Virol., December 1, 2005; 79(23): 14933 - 14944. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
