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Suppression of in vitro Neutrophil Function by Feline Leukaemia Virus (FeLV) and Purified FeLV-p15E

¹ Department of Veterinary Pathobiology,
and The² Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, U.S.A.

Feline neutrophils (PMN) were isolated and exposed to ultraviolet light-inactivated feline leukaemia virus (UV-FeLV) and purified envelope component p15E (FeLV-p15E). Functional capacity of exposed PMN was measured in vitro utilizing the chemiluminescence (CL) response. PMN exposed to UV-FeLV demonstrated depressed CL responses to Ca²⁺-ionophore A23187 [GenBank] and latex particles. However, FeLV-p15E produced significant suppression in the CL response to A23187 [GenBank] but failed to produce significant alterations in response to latex particles. The data indicate that FeLV-p15E may, in part, be responsible for increased morbidity and mortality among FeLV-infected cats through suppression of the PMN population.

Keywords: FeLV, envelope protein, neutrophils

Received 28 May 1986; accepted 13 October 1986.