HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ito, Y. Articles by Yamada, A. Search for Related Content PubMed PubMed Citation Articles by Ito, Y. Articles by Yamada, A. Agricola Articles by Ito, Y. Articles by Yamada, A.

Immunological Interrelationships Among Human and Non-human Paramyxoviruses Revealed by Immunoprecipitation

¹ Department of Microbiology, Mie University School of Medicine, 2-174, Edobashi, Tsu-Shi, Mie 514
and² Department of Measles Virus, National Institute of Health, 4-7-1, Gakuen, Musashi-Murayama-Shi, Tokyo 190-12, Japan

Antigenic interrelationships among paramyxoviruses were examined by immunoprecipitation of isotope-labelled virus-infected cell lysates with specific antisera against virions or virus components. Sendai virus, human parainfluenza virus type 1 (Pa-1) and human parainfluenza virus type 3 (Pa-3) belonged to one antigenic group, and human parainfluenza virus type 2 (Pa-2), human parainfluenza virus type 4 (Pa-4), mumps virus (MuV) and simian virus 5 to a second group. Furthermore, the human paramyxoviruses Pa-1, Pa-2, Pa-3, Pa-4 and MuV formed a single antigenic group which overlapped the above groups. Although Newcastle disease virus (NDV) belonged to a separate group it showed some cross-reaction with the human paramyxoviruses. In particular, certain batches of anti-NDV antisera reacted with the fusion (F) polypeptide of Pa-2 and the reciprocal reaction of anti-Pa-2 antiserum with NDV F was also found. The nucleoprotein showed the broadest cross-reactions among these paramyxoviruses, whereas the matrix polypeptide exhibited antigenic individuality. The nucleoprotein of MuV was most cross-reactive. Pa-2 haemagglutininneuraminidase (HN) and anti-MuV HN serum showed cross-reactivity with various antisera and antigens.

Keywords: paramyxoviruses, antigenic groups, immunoprecipitation

Received 8 September 1986; accepted 22 December 1986.

This article has been cited by other articles:

				H. Miyata, T. Kanazawa, K. Shibuya, and S. Hino Contamination of a specific-pathogen-free rat breeding colony with Human parainfluenzavirus type 3 J. Gen. Virol., March 1, 2005; 86(3): 733 - 741. [Abstract] [Full Text] [PDF]

				M. Ito, T. Takeuchi, M. Nishio, M. Kawano, H. Komada, M. Tsurudome, and Y. Ito Early Stage of Establishment of Persistent Sendai Virus Infection: Unstable Dynamic Phase and Then Selection of Viruses Which Are Tightly Cell Associated, Temperature Sensitive, and Capable of Establishing Persistent Infection J. Virol., November 1, 2004; 78(21): 11939 - 11951. [Abstract] [Full Text] [PDF]